HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Iodophenol → 4-(4-Iodo-phenoxymethyl)-2-methylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Iodophenol | HCID 10894 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(Chloromethyl)-2-methylquinoline | HCID 11535719 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-(4-Iodo-phenoxymethyl)-2-methylquinoline | HCID 21898059 | 100% |
Reaction Steps
To a CH3CN (200 mL) solution of 4-chloromethyl-2-methylquinoline (10.22 g, 53.3 mmol) and 4-iodophenol (11.98 g, 1.02 eq) was added K2CO3. The suspension was heated to reflux for 6 h. The mixture was then filtered through Celite® while the solution was still hot. The 4-(4-iodo-phenoxymethyl)-2-methylquinoline (20 g, 100%) was obtained as fine crystals after recrystalization in CH3CN.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07132432B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-807086318fd34bdab4665794adabbdc5 |
| Source note | uspto-grants-2006_11 |