Hydrochloric Acid → HCID 69526744, compound

Participants

Reaction Steps

HCl in dioxane (4.0M, 9 ml) was added drop-wise with stirring over 1 minute to (2R, 3S) (2-methyl-4-oxo-tetrahydrofuran-3-yl)carbamic acid tert-butyl ester (0.372 g, 1.73 mmol). The mixture was stirred for 20 minutes then the solvents evaporated in vacuo to leave a residue which was azeotroped with toluene (2×20 ml) to leave (4S, 5R) 4amino-5-methyl-dihydro-furan-3-one hydrochloride as a white solid (266 mg, 100%). HPLC-MS, Rt=0.419 mins, 116.1 [M+H]+).

Provenance & Evidence