1-Propanol, 3-amino-2,2-dimethyl- → HCID 10295552, compound

Participants

Reaction Steps

Prepared according to the method described in Example 2 from 2-chloro-5-formyl-N-(tricyclo [3.3.1.13,7]dec-1-ylmethyl)-benzamide (0.150 g, Example 1b), 3-amino-2,2-dimethylpropanol (0.093 g) and sodium triacetoxyborohydride (0.134 g) in 1,2-dichloroethane (6 ml). After work-up, the residue was purified by NPHPLC eluting with a gradient of 0–10% ethanol in dichlorometane to give the title compound as a white powder (0.035 g).

Provenance & Evidence