反应详情

To a methanol (18 mL, 1.14 M) solution containing L-penicillamine (3.0 g, 20.11 mmol, 1.0 eq) was added thionyl chloride (1.5 mL, 20.7 mmol, 1.03 eq). The resulting mixture was heated to reflux for 18 hr and the solvent removed in vacuo. The resulting clear semi-solid was used in the next step without further purification. Isolated 3.28 g (20.1 mmol, 100% yield).

1. temperatureThe resulting mixture was heated
2. temperatureto reflux for 18 hr
3. customthe solvent removed in vacuo
4. customThe resulting clear semi-solid was used in the next step without further purification
5. customIsolated 3.28 g (20.1 mmol, 100% yield)