HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-(4-Nitrophenyl)pyrrolid-3-yl methanesulphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 1-(4-Nitrophenyl)pyrrolidin-3-ol | HCID 12067813 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(4-Nitrophenyl)pyrrolid-3-yl methanesulphonate | HCID 12067814 | — |
Reaction Steps
40 ml (0.516 mol) of mesyl chloride were added dropwise at 5° C. to 83.3 g (0.4 mol) of N-(4-nitrophenyl)-3-hydroxypyrrolidine dissolved in 625 ml of anhydrous THF and 72.7 ml (0.6 mol) of triethylamine. The mixture was allowed to return to room temperature and was then poured into ice to form a precipitate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07132534B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-0de0dbf685c24b13abeb0f7d4f31d80e |
| Source note | uspto-grants-2006_11 |