反应详情

22 g (0.0767 mol) of 1-(4-nitrophenyl)pyrrolid-3-yl methanesulphonate (2) were heated at 95° C. for 2 hours in 170 g of imidazole (2.5 mol), This mixture was poured into 1 l of ice-cold water until crystallization takes place. After filtration and drying, the yellow powder obtained was chromatographed, eluting with dichloromethane, and 14.5 g of derivative (3) were recovered (73.2% yield).

1. filtrationAfter filtration
2. customdrying
3. customthe yellow powder obtained
4. customwas chromatographed
5. washeluting with dichloromethane, and 14.5 g of derivative (3)
6. customwere recovered (73.2% yield)