反应详情

30 g (0.105 mol) of 1-(4-nitrophenyl)pyrrolid-3-yl methylsulphonate (2) were heated at 90° C. for 18 hours with 120 g of aminopropylimidazole (0.958 mol). This mixture was poured into ice-cold water and the product was extracted with dichloromethane. The yellow powder obtained was chromatographed, eluting with dichloromethane/methanol (98/2), and 15.2 g of derivative (7) were recovered (48.2% yield).

1. additionThis mixture was poured into ice-cold water
2. extractionthe product was extracted with dichloromethane
3. customThe yellow powder obtained
4. customwas chromatographed
5. washeluting with dichloromethane/methanol (98/2), and 15.2 g of derivative (7)
6. customwere recovered (48.2% yield)