2-Mercaptoethanol → 4'-(2-Hydroxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid ethyl ester

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Reaction Steps

4′-(2-Hydroxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid ethyl ester was prepared as described for 4′-(2-hydroxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid ethyl ester. 4′-Bromomethyl-biphenyl-4-carboxylic acid ethyl ester (4.2 g, 13.16 mmol, 1 eq.) in anhydrous DMF (100 mL) was treated with potassium carbonate (5.46 g, 39.48 mmol, 3 eq.) and 2-mercaptoethanol (1.23 g, 15.79 mmol, 1.2 eq.). When the reaction was complete, the reaction was worked up as described leaving a yellow oil upon removal of the solvent.

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