2-Mercaptoethanol → 3'-(2-Hydroxy-ethylsulfanylmethyl)-biphenyl-2-carboxylic acid ethyl ester

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Reaction Steps

3′-(2-Hydroxy-ethylsulfanylmethyl)-biphenyl-2-carboxylic acid ethyl ester was prepared as described for 4′-(2-hydroxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid ethyl ester. 3′-Bromomethyl-biphenyl-2-carboxylic acid ethyl ester (5.4 g, 16.92 mmol, 1 eq.). in anhydrous DMF was treated with 2-mercaptoethanol (1.59 g, 20.30 mmol, 1.2 eq.) and potassium carbonate (7.02 g, 50.76 mmol, 3 eq.). When complete, the reaction was worked up as described leaving a light yellow oil.

Provenance & Evidence