Azobisisobutyronitrile → Ethyl 3'-(bromomethyl)biphenyl-3-carboxylate

Participants

Reaction Steps

3′-Bromomethyl-biphenyl-3-carboxylic acid ethyl ester was synthesized as described for 4′-bromomethyl-biphenyl-3-carboxylic acid ethyl ester. 3′-Methyl-biphenyl-3-carboxylic acid ethyl ester (4.2 g, 17.48 mmol, 1 eq.) in carbon tetrachloride was treated with N-bromosuccinimide (3.73 g, 20.98 mmol, 1.2 eq.) and 2,2′-azobisisobutyronitrile (0.14 g, 0.87 mmol, 5 mol %). When complete, the reaction was worked up as described leaving an orange oil.

Provenance & Evidence