4-Dimethylaminobutylamine → 3'-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid (4-dimethylamino-butyl)-amide

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Reaction Steps

3′-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid (4-dimethylamino-butyl)-amide was synthesized as described for 4′-(2-phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid (3-dimethylamino-propyl)-amide. 3′-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid (1.50 g, 4.12 mmol, 1 eq.) in anhydrous THF was treated with 1,1-carbonyldiimidazole (0.68 g, 4.20 mmol, 1.02 eq.) and 4-dimethylaminobutylamine (0.57 g, 4.94 mmol, 1.2 eq.). When complete, the reaction was worked up as described leaving a yellow oil.

Provenance & Evidence