2-Mercaptoethanol → 2'-(2-Hydroxy-ethylsulfanylmethyl)-biphenyl-2-carboxylic acid ethyl ester

Participants

Reaction Steps

2′-(2-Hydroxy-ethylsulfanylmethyl)-biphenyl-2-carboxylic acid ethyl ester was synthesized as described for 4′-(2-hydroxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid ethyl ester. 2′-Bromomethyl-biphenyl-2-carboxylic acid ethyl ester (13.2 g, 41.35 mmol, 1 eq.) in anhydrous DMF was treated with 2-mercaptoethanol (3.88 g, 49.62 mmol, 1.2 eq.) and potassium carbonate (17.14 g, 124.05 mmol, 3 eq.). When complete, the reaction was worked up as described leaving an orange oil.

Provenance & Evidence