HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 2'-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 4'-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid | HCID 21899992 | — |
| Reactant | 2'-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid ethyl ester | HCID 58610592 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2'-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid | HCID 21899983 | — |
Reaction Steps
2′-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid was synthesized as described for 4′-(2-phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid. 2′-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid ethyl ester (4.75 g, 12.10 mmol, 1 eq.) in 30% aqueous THF was treated with lithium hydroxide (0.87 g, 36.30 mmol, 3 eq.). When complete, the reaction was worked up as described leaving a tan solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07132456B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-b62a842ba0a04f6d82840ee17a529762 |
| Source note | uspto-grants-2006_11 |