HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 2671294, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (4-Aminophenoxy)benzene | HCID 8764 | — |
| Reactant | Benzoyl chloride, 2-chloro-5-nitro- | HCID 117637 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 2671294 | HCID 2671294 | 87.3% |
Reaction Steps
Into 5 mL of a tetrahydrofuran solution comprising 420 mg of 4-phenoxyaniline and 250 mg of triethylamine, 5 mL of a tetrahydrofuran solution comprising 500 mg of 2-chloro-5-nitrobenzoylchloride was dropwise added under cooling with ice. After stirring for about 30 minutes, water was added thereto, and precipitated crystals were collected by filtration. The collected crystals were washed with water and then dried to obtain 730 mg of N-(4-phenoxyphenyl)-2-chloro-5-nitrobenzamide (Compound No. 27) having a melting point of 128° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07132546B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-d834af01c46d421cb9366e1c9b0ed8b1 |
| Source note | uspto-grants-2006_11 |