Tetrahydrofuran → HCID 12087762, compound

Participants

Reaction Steps

To 5 mL of a tetrahydrofuran solution comprising 670 mg of 4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)-3-methylaniline and 270 mg of triethylamine, 5 mL of a tetrahydrofuran solution comprising 490 mg of 2-chloro-5-nitrobenzoylchloride was dropwise added, followed by stirring for about 30 minutes, and then water was added, and the precipitated crystals were collected by filtration. The collected crystals were washed with water and then dried to obtain 700 mg of N-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)-3-methylphenyl)-2-chloro-5-nitrobenzamide (Compound No. 106) having a melting point of from 230 to 232° C.

Provenance & Evidence