Tetrahydrofuran → HCID 12087763, compound

Participants

Reaction Steps

To 5 mL of a tetrahydrofuran solution comprising 290 mg of 5-amino-2-(1-adamantyloxy)pyridine) and 150 mg of triethylamine, 5 mL of a tetrahydrofuran solution comprising 260 mg of 2-chloro-5-nitrobenzoylchloride was dropwise added, followed by stirring for about 30 minutes, and then water was added, and the precipitated crystals were collected by filtration. The collected crystals were washed with water and then dried to obtain 330 mg of N-(2-(1-adamantyloxy)-5-pyridyl)-2-chloro-5-nitrobenzamide (Compound No. 123) having a melting point of from 98 to 105° C.

Provenance & Evidence