Tetrahydrofuran → HCID 12087764, compound

Participants

Reaction Steps

To 5 mL of a tetrahydrofuran solution comprising 300 mg of 4-(3-chloro-5-trifluoromethyl-2-pyridylmethyloxy)aniline and 120 mg of triethylamine, 5 mL of a tetrahydrofuran solution comprising 220 mg of 2-chloro-5-nitrobenzoylchloride was dropwise added, followed by stirring for about 30 minutes, and then water was added thereto, and the precipitated crystals were collected by filtration. The collected crystals were washed with water and then dried to obtain 380 mg of N-(4-(3-chloro-5-trifluoromethyl-2-pyridylmethyloxy)phenyl)-2-chloro-5-nitrobenzamide (Compound No. 135) having a melting point of from 193 to 195° C.

Provenance & Evidence