HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-[3-(4-piperidinyl)propanoyl]1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one → 8-(3-{1-[2-(2-Chlorophenyl)ethyl]-4-piperidinyl}propanoyl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2, 1-ij]quinolin-4-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-[3-(4-piperidinyl)propanoyl]1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one | HCID 9966544 | — |
| Reactant | 2-(2-Chlorophenyl)ethyl methanesulfonate | HCID 21888087 | — |
| Product | 8-(3-{1-[2-(2-Chlorophenyl)ethyl]-4-piperidinyl}propanoyl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2, 1-ij]quinolin-4-one hydrochloride | HCID 21887350 | 61.4% |
Reaction Steps
Using 8-[3-(4-piperidinyl)propanoyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (600 mg) and 2-(2-chlorophenyl)ethyl methanesulfonate (475 mg) according to the same method as that of Example 81, the title compound (303 mg) was obtained as colorless crystals having a melting point of 207 to 210° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07132547B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-cfe12279c7c74765a0539a6d311d8484 |
| Source note | uspto-grants-2006_11 |