HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-1,2,3,4-tetrahydronaphthalene → (+/-)-8-{3-[1-(1,2,3,4-Tetrahydro-1-naphthalenyl)-4-piperidinyl]propanoyl}-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-1,2,3,4-tetrahydronaphthalene | HCID 188717 | — |
| Reactant | 8-[3-(4-piperidinyl)propanoyl]1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one | HCID 9966544 | — |
| Product | (+/-)-8-{3-[1-(1,2,3,4-Tetrahydro-1-naphthalenyl)-4-piperidinyl]propanoyl}-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one hydrochloride | HCID 21887715 | 5.6% |
Reaction Steps
Using 8-[3-(4-piperidinyl)propanoyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (500 mg) and (±)-1-chloro-1,2,3,4-tetrahydronaphthalene (280 mg) according to the same method as that of Example 330, the title compound (43 mg) was obtained as pale yellow amorphous powders.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07132547B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-65e9397d68d648e48a2a5e4cc5c1b2e9 |
| Source note | uspto-grants-2006_11 |