Oxalic Acid → HCID 21887847, compound

HRID 719835Notes

Reaction equation

Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([C:18]1[CH:19]=[C:20]2[C:25]3=[C:26]([CH2:28][C:29](=[O:30])[N:24]3[CH2:23][CH2:22][CH2:21]2)[CH:27]=1)=[O:17].[C:31]([OH:36])(=[O:35])[C:32]([OH:34])=[O:33]>>[C:31]([OH:36])(=[O:35])[C:32]([OH:34])=[O:33].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([C:18]1[CH:19]=[C:20]2[C:25]3=[C:26]([CH2:28][C:29](=[O:30])[N:24]3[CH2:23][CH2:22][CH2:21]2)[CH:27]=1)=[O:17]

Participants

Reactant 2

HCID 971Oxalic Acid

HCID 21887313HCID 21887313, compound

Product 1

HCID 21887847HCID 21887847, compound

Procedure

Using 8-(5-{[2-(2-chlorophenyl)ethyl]amino}pentanoyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2 (1H)-one hydrochloride (205 mg, 0,5 mmol) obtained in Example 39 and oxalic acid (45 mg, 0.5 mmol) according to the same method as that of Example 360, the title compound was obtained as colorless crystals (221 mg) having a melting point of 161 to 163° C. (dec).

Sources & evidence

ORD record: ord-1613439be3ac4d71bb462b15aa1cd772
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07132547B2

Reaction notes

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