反应详情

6-Methoxy-2H-isoquinolin-1-one in POCl3 was heated to gentle reflux for 3 h then evaporated in vacuo. The residue was poured into ice-water (20 mL) and neutralized to pH 10 with 10 M NaOH. Extracted with CHCl3. The organic layer was washed with brine, dried over MgSO4, filtered, evaporated. The residue was purified by flash chromatography (hexane-EtOAc) to afford a white solid.

1. temperatureto gentle reflux for 3 h
2. customthen evaporated in vacuo
3. additionThe residue was poured into ice-water (20 mL)
4. extractionExtracted with CHCl3
5. washThe organic layer was washed with brine
6. dry with materialdried over MgSO4
7. filtrationfiltered
8. customevaporated
9. customThe residue was purified by flash chromatography (hexane-EtOAc)
10. customto afford a white solid