Sodium Carbonate → HCID 178504750, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-N-(5-cyano-pyridin-2-yl)-3-cyclopentyl-propionamide (74 mg, 0.17 mmol) in ethanol (1 mL) and water (0.5 mL) was treated with hydroxylamine hydrochloride (14 mg, 0.21 mmol) and sodium carbonate (9 mg, 0.08 mmol). This solution was then heated at 70° C. for 1.5 h, after which time, the product precipitated out of solution. The resulting solid was collected by filtration, washed with water, and dried under vacuum to afford 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-[5-(N-hydroxycarbamimidoyl)-pyridin-2-yl]-propionamide (27 mg, 34%) as a white solid: (ES)+-HRMS m/e calcd for C21H25ClN4O4S (M+H)+ 465.1358, found 465.1362.

Provenance & Evidence