Trifluoroacetic acid → HCID 67482613, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid tert-butyl ester (3.29 g, 6.48 mmol) in methylene chloride (30 mL) was treated with trifluoroacetic acid (60 mL) and stirred at 25° C. for 65 min. The reaction solution was then concentrated in vacuo The resulting oil was diluted with ethyl acetate (500 mL), washed with water (2×250 mL) and a saturated aqueous sodium chloride solution (5×250 mL), dried over sodium sulfate, treated with decolorizing carbon, filtered through a pad of celite, and concentrated in vacuo to afford the 5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid (2.89 g, 99%) as a light yellow foam: mp 121–127° C.; (ES)+-HRMS m/e calcd for C20H22ClN3O5S (M+H)+ 452.1042, found 452.1046. This material was used without further purification.

Provenance & Evidence