Ammonium formate → HCID 67482815, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-(5-nitro-pyrazin-2-yl)-malonic acid diethyl ester (425 mg, 1.5 mmol) in ethanol (10 mL) at 25° C. was treated with ammonium formate (510 mg, 8.1 mmol) and 10% palladium on activated carbon (51 mg). The mixture was heated to 95–100° C. for 4 h and then was stirred at 25° C. overnight. At this time, the catalyst was removed by filtration through a pad of celite (ethanol wash). The filtrate was concentrated in vacuo. Biotage chromatography (FLASH 40M, Silica, 1/1 ethyl acetate/hexanes) afforded 2-(5-amino-pyrazin-2-yl)-malonic acid diethyl ester (131.5 mg, 37%) as a light tan solid: EI-HRMS m/e calcd for C11H15N3O4 (M+) 253.1063, found 253.1065.

Provenance & Evidence