Ethyl Acetate → HCID 21897209, compound

Participants

Reaction Steps

A solution of 5-[1,3]dioxolan-2-ylmethyl-pyrazin-2-yl-carbamic acid benzyl ester (240 mg, 0.49 mmol) in methanol (5 mL) was treated with 10% palladium on activated carbon (40 mg). The reaction mixture was then hydrogenated under a hydrogen atmosphere at 25° C. and atmospheric pressure for 60 min, at which time, thin layer chromatography (ethyl acetate) suggested complete conversion to a polar product. The reaction was filtered through celite, and the filtrate was concentrated in vacuo to afford 5-[1,3]dioxolan-2-ylmethyl-pyrazin-2-ylamine (140 mg, 100%) as an oil which crystallized.

Provenance & Evidence