Allyl Alcohol → HCID 67482524, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 5-chloropyrazine-2-carboxylate (1.7 g, 10 mmol) and allyl alcohol (10 mL, 147 mmol) was heated with stirring to 95° C. and then treated with pulverized potassium hydroxide (1.3 g, 23 mmol). Within 10 min, a thick paste developed. The heating was continued for 2 h. The reaction mixture was concentrated in vacuo to dryness, and the residue was further concentrated in vacuo to dryness from toluene (2×50 mL). The 5-allyloxy-pyrazine-2-carboxylic acid potassium salt (2.2 g) that was isolated was used without further purification and characterization.

Provenance & Evidence