HCID 67482843, compound → HCID 21897357, compound

Participants

Reaction Steps

A solution of {5-[2-(tetrahydro-pyran-2-yl)-ethoxy]-pyrazin-2-yl}-carbamic acid benzyl ester (560 mg, 1.5 mmol) in tetrahydrofuran (5 mL) and methanol (15 mL) was treated with 10% palladium on activated carbon (110 mg) in methanol (5 mL). The reaction mixture was stirred under a positive pressure of hydrogen gas (balloon) at 25° C. for 2 h, at which time, thin layer chromatography indicated complete removal of the protection group. The reaction mixture was filtered and concentrated in vacuo to afford 5-[2-(tetrahydro-pyran-2-yl)-ethoxy]-pyrazin-2-ylamine as an oil which was used without further purification.

Provenance & Evidence