Sodium Hydroxide → HCID 21897288, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 2,2-dimethyl-N-[5-(4-methyl-2,5-dioxo-imidazolidin-4-yl)-pyrazin-2-yl]-propionamide (1.16 g, 4.0 mmol) in methanol (30 mL) was treated with a 1N aqueous sodium hydroxide solution (15 mL). The mixture was heated at 65° C. for 4 h and at 25° C. overnight. The mixture was concentrated in vacuo, and the residue was dried in vacuo overnight to give a crude solid. This solid material was suspended in a mixture of ethyl acetate and methanol (100 mL, 1:1) and gently heated. The mixture was filtered, and the filtrate was concentrated in vacuo. Biotage chromatography (FLASH 40L, Silica, 1/9 to 3/7 methanol/ethyl acetate) afforded 5-(5-amino-pyrazin-2-yl)-5-methyl-imidazolidine-2,4-dione (841 mg, 100%) as a solid.

Provenance & Evidence