4-Fluorophenol → HCID 21901973, compound

HRID 720030Notes

Reaction equation

HRID 720030 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Cs+].[Cs+].O1C2C=CC(O[CH2:25][CH:26]3[CH2:31][CH2:30][CH2:29][N:28]([C:32]([C:34]4([C:38]5[CH:43]=[CH:42][C:41]([Cl:44])=[CH:40][CH:39]=5)[CH2:37][CH2:36][CH2:35]4)=[O:33])[CH2:27]3)=CC=2OC1>>[Cl:44][C:41]1[CH:42]=[CH:43][C:38]([C:34]2([C:32]([N:28]3[CH2:29][CH2:30][CH2:31][CH:26]([CH2:25][O:8][C:5]4[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=4)[CH2:27]3)=[O:33])[CH2:37][CH2:36][CH2:35]2)=[CH:39][CH:40]=1

Participants

4

Reactant 3

HCID 97324-FluorophenolHCID 10796Cesium carbonateHCID 21902076HCID 21902076, compound

Product 1

HCID 21901973HCID 21901973, compound

Procedure

Compound 84 was synthesized from 4-fluorophenol (0.29 g, 2.60 mmol), cesium carbonate (1.27 g, 3.89 mmol) and compound 43 (1.0 g, 2.60 mmol), using the method described for the synthesis of compound 44 to give 0.60 g of the desired product 84. C23H25ClFNO2, LRMS (m/z)=402 (MH+).

Sources & evidence

ORD record
ord-430b19f7ea1a45e28a15ddabdadd86ff
Source dataset
uspto-grants-2006_11
Patent number
US07132551B2

Reaction notes

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