Aluminium lithium hydride → HCID 58737516, compound

HRID 720032Notes

Reaction equation

HRID 720032 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:12]([N:14]3[CH2:19][CH2:18][CH2:17][CH:16]([CH2:20][O:21][C:22]4[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=4)[CH2:15]3)=O)[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([CH2:12][N:14]3[CH2:19][CH2:18][CH2:17][CH:16]([CH2:20][O:21][C:22]4[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=4)[CH2:15]3)[CH2:9][CH2:10][CH2:11]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21901973HCID 21901973, compound

Product 1

HCID 58737516HCID 58737516, compoundYield 49.5%

Procedure

Compound 86 was synthesized from compound 84 (0.50 g, 1.25 mmol) and lithium aluminum hydride (0.10 g), using the method described for the synthesis of compound 83 to give 0.24 g of the desired product 86. C23H27ClFNO, LRMS (m/z)=388 (MH+).

Sources & evidence

ORD record
ord-a013cbca4760458aaa00931ef4bf63f7
Source dataset
uspto-grants-2006_11
Patent number
US07132551B2

Reaction notes

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