Aluminium lithium hydride → HCID 58737529, compound

HRID 720033Notes

Reaction equation

HRID 720033 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:12]([N:14]3[CH2:19][CH2:18][CH2:17][CH:16]([CH2:20][O:21][C:22]4[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=4)[CH2:15]3)=O)[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:12][N:14]3[CH2:19][CH2:18][CH2:17][CH:16]([CH2:20][O:21][C:22]4[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=4)[CH2:15]3)[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21901945HCID 21901945, compound

Product 1

HCID 58737529HCID 58737529, compoundYield 41%

Procedure

Compound 87 was synthesized from compound 85 (0.50 g, 1.25 mmol) and lithium aluminum hydride (0.10 g), using the method described for the synthesis of compound 83 to give 0.19 g of the desired product 87. C22H27ClN2O, LRMS (m/z)=371 (MH+).

Sources & evidence

ORD record
ord-1bc7e0d37aac459081400e09109d1688
Source dataset
uspto-grants-2006_11
Patent number
US07132551B2

Reaction notes

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