Sodium borohydride → HCID 21901931, compound

HRID 720061Notes

Reaction equation

HRID 720061 reaction equation
[BH4-].[Na+].[O:3]1[C:7]2[CH:8]=[CH:9][C:10]([O:12][CH2:13][CH:14]3[CH2:19][CH2:18][CH2:17][N:16]([CH2:20][C:21]([C:23]4([C:27]5[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=5[O:33][CH3:34])[CH2:26][CH2:25][CH2:24]4)=[O:22])[CH2:15]3)=[CH:11][C:6]=2[O:5][CH2:4]1>CO>[O:3]1[C:7]2[CH:8]=[CH:9][C:10]([O:12][CH2:13][CH:14]3[CH2:19][CH2:18][CH2:17][N:16]([CH2:20][CH:21]([C:23]4([C:27]5[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=5[O:33][CH3:34])[CH2:24][CH2:25][CH2:26]4)[OH:22])[CH2:15]3)=[CH:11][C:6]=2[O:5][CH2:4]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 21902072HCID 21902072, compound

Product 1

HCID 21901931HCID 21901931, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-[3-(Benzo[1,3]dioxol-5-yloxymethyl)-piperidin-1-yl]-1-[1-(2-methoxy-phenyl)-cyclobutyl]-ethanol (232) was prepared according to the procedures outlined in Example 138, using sodium borohydride (17 mg, 0.453 mmol), and 2-[3-(benzo[1,3]dioxol-5-yloxymethyl)-piperidin-1-yl]-1-[1-(2-methoxy-phenyl)-cyclobutyl]-ethanone (100 mg, 0.227 mmol) in MeOH (1.6 mL); MS+ (440).

Sources & evidence

ORD record
ord-8d0e29260aac42839d3a3da8fc979bab
Source dataset
uspto-grants-2006_11
Patent number
US07132551B2

Reaction notes

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