HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 720069Generated: October 27, 2026
Methanesulfonyl chloride → n-(6-Oxo-2-phenyl-5,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)-methanesulfonamide
https://huagongshe.com/reaction/720069
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 8-Amino-2-phenyl-1,5-dihydro-[1,2]diazepino[4,5,6-cd]indol-6-one | HCID 135774079 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | n-(6-Oxo-2-phenyl-5,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)-methanesulfonamide | HCID 135774153 | 30% |
Reaction Steps
Methanesulfonyl Chloride (1.5 eq, 0.003 g) was added to a solution of the title compound of Example 7 (0.005 g, 0.018 mmol) in CH2Cl2 (0.045 M, 0.4 mL) and pyridine (0.045 M, 0.4 mL). The mixture stirred at 22° C. for 24 hours and concentrated under reduced pressure. Silica gel chromatography (triethylamine/methanol/CH2Cl2; 1:5:94) afforded the title compound (1.7 mg) in 30% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07132533B2 |
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| Source dataset | uspto-grants-2006_11 |
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| ORD ID | ord-93f7a0c507734f64851276e7e75484d5 |
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| Source note | uspto-grants-2006_11 |
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