Benzylamine → HCID 135774181, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-Chloro-N-[2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-acetamide 270(a) (100 mg, 0.28 mmol) in DMF (1.5 mL) was added Cs2CO3 (˜5 eq.) followed by benzyl amine (33 mg, 0.3 mmoL). The resulting mixture was heated at 50° C. overnight. Excess Cs2CO3 was filtered and the clear dark solution was purified by reverse phase HPLC to afford 15 mg of desired product as yellow solids.

Provenance & Evidence