Trifluoroacetic acid → HCID 72406547, compound

Participants

Reaction Steps

3-[2-(2-Allyl-4-benzyloxy-pyrrolidin-1-yl)-1-(4-fluorobenzyl)-2-oxo-ethylcarbamoyl]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester, 55, (200 mg) is dissolved into CH2Cl2 (3 mL) and trifluoroacetic acid (1 mL) is added. The reaction mixture is stirred for 5 hours and concentrated. The residue is purified by reverse phase HPLC to afford 50 mg of the desired product. 1H NMR (CDCl3, 300 MHz) δ 6.80˜7.50 (m, 13H), 5.75 (m, 1H), 5.06 (m, 2H), 4.30˜4.70 (m, 6H), 4.06 (m, 2H), 3.75 (m, 1H), 2.90˜3.30 (m, 6H), 2.69 (m, 1H), 2.23 (m, 1H), 1.80˜2.00 (m, 2H); MS (ES-MS) m/z 542 (M+1).

Provenance & Evidence