HCID 21889067, compound → HCID 21889077, compound

Participants

Reaction Steps

40 g N-3-(morpholin4-yl)propyl-3-nitroaniline was dissolved in 450 ml ethanol and 50 ml water, and 0.5 Pd/C (5%) was added. After purging with nitrogen, hydrogenation was performed for 12 h at 50° C. under 50 bar of hydrogen pressure. After cooling, nitrogen purging was repeated, the catalyst was filtered off, and the filtrate was reduced in a rotary evaporator. 32.2 g of pasty black oil was obtained; this was distilled in a ball tube (220–232° C., 0.06–0.08 mbar). The product obtained was a crystalline orange material.

Provenance & Evidence