Thiophene-3-carboxylic acid → 5-Bromothiophene-3-carboxylic acid

Participants

Reaction Steps

To a solution of thiophene-3-carboxylic acid (25 g, 195 mmol) in AcOH (700 ml) was added bromine (10.6 ml) in AcOH (200 ml) dropwise. After the addition, the reaction was stirred for 30 minutes at room temperature and poured onto water. A white precipitate was formed, which was filtered and dried to obtain 5-bromo-thiophene-3-carboxylic acid (14.5 g) as a white solid after crystallization (water).

Provenance & Evidence