反应详情

A solution of 5-bromo-thiophene-3-carboxylic acid (14.5 g, 70 mmol) was dissolved in SOCl2 and the mixture was refluxed for 2 hours. The mixture was concentrated under reduced pressure to give a yellow oil. The oil was was dissolved in EtOH and the mixture was refluxed for 1 hour, then concentrated under reduced pressure to give 5-bromo-thiophene-3-carboxylic acid ethyl ester as an oil (16.46 g, quantitative).

1. temperaturethe mixture was refluxed for 2 hours
2. concentrationThe mixture was concentrated under reduced pressure
3. customto give a yellow oil
4. temperaturethe mixture was refluxed for 1 hour
5. concentrationconcentrated under reduced pressure