HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → tert-Butyl (1S,2S)-1-amino-2-ethylcyclopropane-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | (1S,2S) 2-Ethyl-1-(2trimethylsilanylethoxycarbonylamino)cyclopropane-carboxylic acid tert-butyl ester | HCID 86601847 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | tert-Butyl (1S,2S)-1-amino-2-ethylcyclopropane-1-carboxylate | HCID 86620254 | — |
Reaction Steps
To the product of Step 3 (3 g, 9 mmol) was added a 1.0 M TBAF solution in THF (9.3 mL, 9.3 mmol) and the mixture heated to reflux for 1.5 h, cooled to rt and then diluted with 500 ml of EtOAc. The solution was successively washed with water (2×100 mL), brine (2×100 mL), dried (MgSO4), concentrated in vacuo to provide the title intermediate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07135462B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-039f15e3488d476f92f8529617b0e6ac |
| Source note | uspto-grants-2006_11 |