HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → HCID 86586427, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | tert-Butoxy bis(dimethylamino)methane | HCID 79885 | — |
| Reactant | 2-(Pyridin-4-yl)acetonitrile | HCID 4112085 | — |
| Solvent | Dichloromethane ethylacetate | HCID 21226138 | — |
| Product | HCID 86586427 | HCID 86586427 | — |
Reaction Steps
4-Pyridylacetonitrile 7.52 g (63.7 mmol) and tert-butoxybis(dimethylamino)methane 11.09 g (63.7 mmol) are stirred at 100° C. for 2 h. During this, liberated dimethylamine and t-butanol is discharged to the atmosphere by means of a vacuum pump through a gentle reduced pressure flow. Flash chromatography (dichloromethane/ethyl acetate 50:1->20:1) affords the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07135474B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-cd6c66ffbebc4796948be8717299d0df |
| Source note | uspto-grants-2006_11 |