反应详情

30.37 g (562 mmol) of sodium methoxide are dissolved in 1.5 l of methanol, and 36.45 g (144.5 mmol) of 3-cyano-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine (from Example 33 A-4) are added. The mixture is stirred at room temperature for 2 hours and the resulting solution is employed directly for the next stage.