N,N-Dimethylglycine → HCID 58739187, compound

Participants

Reaction Steps

A mixture of dimethylamino-acetic acid (0.083 mmol), (S)-1-(3-pyridin-3-yl-phenyl)-ethylamine (12.7 mg, 0.064 mmol), EDAC.HCl (18.4 mg, 0.096 mmol), HOBT (13 mg, 0.096 mmol) and diisopropylethylamine (33 μL, 0.192 mmol) in DMF (2 mL) was stirred at room temperature for 18 h, and the reaction mixture was purified by preparative HPLC (5 mM NH4OAc buffer; gradient 0% to 100% B in 10 min (A: 10% CH3CN/H2O ; B: 90% CH3CN/H2O; column: Primesphere C18 HC 21.2×100 mm) to afford the title product.

Provenance & Evidence