3-(2-Fluorophenyl)prop-2-enoic acid → HCID 67549975, compound

HRID 720272Notes

Reaction equation

HRID 720272 reaction equation
[F:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([OH:8])=O.[NH2:13][C@H:14]([C:16]1[CH:17]=[C:18]([C:22]2[C:23]([NH2:28])=[N:24][O:25][C:26]=2[CH3:27])[CH:19]=[CH:20][CH:21]=1)[CH3:15]>>[NH2:28][C:23]1[C:22]([C:18]2[CH:17]=[C:16]([C@@H:14]([NH:13][C:6](=[O:8])[CH:5]=[CH:4][C:3]3[CH:9]=[CH:10][CH:11]=[CH:12][C:2]=3[F:1])[CH3:15])[CH:21]=[CH:20][CH:19]=2)=[C:26]([CH3:27])[O:25][N:24]=1

Participants

3

Reactant 2

HCID 679773-(2-Fluorophenyl)prop-2-enoic acidHCID 58739185HCID 58739185, compound

Product 1

HCID 67549975HCID 67549975, compound

Procedure

The title compound was prepared from 2-fluorocinnamic acid and (S)-4-[3-(1-amino-ethyl)-phenyl]-5-methyl-isoxazol-3-ylamine following the general procedures as described for Example 1.

Sources & evidence

ORD record
ord-3d87e6d01ba248b198bab2bd45cb6b22
Source dataset
uspto-grants-2006_11
Patent number
US07135472B2

Reaction notes

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