3-(2-Fluorophenyl)prop-2-enoic acid → HCID 69358327, compound
Reaction equation
[F:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([OH:8])=O.[N:13]1([C:18]2[CH:19]=[C:20]([C@@H:24]([NH2:26])[CH3:25])[CH:21]=[CH:22][CH:23]=2)[CH:17]=[CH:16][N:15]=[CH:14]1>>[F:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([NH:26][C@H:24]([C:20]1[CH:21]=[CH:22][CH:23]=[C:18]([N:13]2[CH:17]=[CH:16][N:15]=[CH:14]2)[CH:19]=1)[CH3:25])=[O:8]Participants
3
Procedure
The title compound was prepared from 2-fluorocinnamic acid and (S)-1-(3-imidazol-1-yl-phenyl)-ethylamine following the general procedures as described for Example 1.
Sources & evidence
- ORD record
- ord-831c6fe489364fb5ae32d78019ceac56
- Source dataset
- uspto-grants-2006_11
- Patent number
- US07135472B2
Reaction notes
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