1-(2-Hydroxyethyl)piperazine → HCID 58739055, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-Benzyloxy-2-methanesulfonyl-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid ethyl ester (0.10 g, 0.27 mmol) dissolved in THF (1 mL) was added 1-(2-hydroxyethyl)piperazine (0.05 mL, 0.41 mmol). The resulting mixture was stirred at 70° C. for 3 hours. The mixture was concentrated and the resulting residue was purified by flash chromatography, eluting with 2% MeOH/CH2Cl2 to yield the title compound as a pale yellow oil (0.0423 g, 38% yield). 1H NMR (500 MHz, CDCl3) δ: 7.45 (2H, d, J=7.0 Hz), 7.35–7.27 (3H, m), 5.14 (2H, s), 4.30 (2H, q, J=7.1 Hz), 3.63 (2H, t, J=5.3 Hz), 3.49 (3H, s), 3.21 (4H, t, J=4.7 Hz), 2.63 (4H, bs), 2.59 (2H, t, J=5.3 Hz), 1.27 (3H, t, J=7.2 Hz). HRMS (M+H) calcd for C21H29N4O5: 417.21381. found: 417.2147.

Provenance & Evidence