Piperazine → HCID 21891291, compound

Participants

Reaction Steps

Following the procedure described for the synthesis of compound 67A 5-Benzyloxy-2-methanesulfonyl-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid ethyl ester (7.0 g, 19.2 mmol) was reacted with piperazine (17.0 g, 192 mmol) and to yield the title compound as a pale yellow oil (0.0418 g, 42% yield). 1H NMR (500 MHz, CDCl3) δ: 7.45 (2H, d, J=6.7 Hz), 7.34–7.27 (3H, m), 5.13 (2H, s), 4.30 (2H, q, J=7.2 Hz), 3.49 (3H, s), 3.15–3.13 (4H, m), 2.98–2.96 (4H, m), 1.89 ( 1H, bs), 1.27 (3H, J=7.2 Hz). HRMS (M+H) calcd for C19H25N4O4: 373.21414. found: 373.1866.

Provenance & Evidence