Hexahydro-1,4-diazepine → N,N'-bis[(5,6,7-trimethoxynaphthalen-2-yl)methyl]homopiperazine

HRID 720305Notes

Reaction equation

HRID 720305 reaction equation
Cl[CH2:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][C:7]([O:17][CH3:18])=[C:8]([O:15][CH3:16])[C:9]=2[O:13][CH3:14])[CH:4]=1.[NH:19]1[CH2:25][CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH3:14][O:13][C:9]1[C:8]([O:15][CH3:16])=[C:7]([O:17][CH3:18])[CH:6]=[C:5]2[C:10]=1[CH:11]=[CH:12][C:3]([CH2:2][N:19]1[CH2:25][CH2:24][CH2:23][N:22]([CH2:2][C:3]3[CH:12]=[CH:11][C:10]4[C:5](=[CH:6][C:7]([O:17][CH3:18])=[C:8]([O:15][CH3:16])[C:9]=4[O:13][CH3:14])[CH:4]=3)[CH2:21][CH2:20]1)=[CH:4]2

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 218916422-Chloromethyl-5,6,7-trimethoxynaphthalene

Product 1

HCID 12108581N,N'-bis[(5,6,7-trimethoxynaphthalen-2-yl)methyl]homopiperazine

Procedure

2-Chloromethyl-5,6,7-trimethoxynaphthalene (607 mg) and homopiperazine (108 mg) were reacted in the same manner in Example 1 to obtain the title compound as a free base.

Sources & evidence

ORD record
ord-d15d646e7e8844859ba3b04bba096cce
Source dataset
uspto-grants-2006_11
Patent number
US07135473B2

Reaction notes

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