Hexahydro-1,4-diazepine → HCID 21891639, compound

HRID 720335Notes

Reaction equation

HRID 720335 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[C:6]([O:15][CH3:16])[C:7]([O:13][CH3:14])=[C:8]([O:11][CH3:12])[CH:9]=2)[CH:4]=[C:3]1[C:17]([OH:19])=O.[NH:20]1[CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[CH3:1][N:2]1[C:10]2[C:5](=[C:6]([O:15][CH3:16])[C:7]([O:13][CH3:14])=[C:8]([O:11][CH3:12])[CH:9]=2)[CH:4]=[C:3]1[C:17]([N:20]1[CH2:26][CH2:25][CH2:24][N:23]([C:17]([C:3]2[N:2]([CH3:1])[C:10]3[C:5]([CH:4]=2)=[C:6]([O:15][CH3:16])[C:7]([O:13][CH3:14])=[C:8]([O:11][CH3:12])[CH:9]=3)=[O:19])[CH2:22][CH2:21]1)=[O:19]

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 907320HCID 907320, compound

Product 1

HCID 21891639HCID 21891639, compound

Procedure

N-Methyl-4,5,6-trimethoxyindole-2-carboxylic acid (130 mg) and homopiperazine (24 mg) were reacted in the same manner as in Preparation Example 37 to obtain the title compound.

Sources & evidence

ORD record
ord-6fd18d1af575470babae3f77df8b815c
Source dataset
uspto-grants-2006_11
Patent number
US07135473B2

Reaction notes

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