Hexahydro-1,4-diazepine → HCID 21891636, compound

HRID 720342Notes

Reaction equation

HRID 720342 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][C:9]1[N:10]([CH3:24])[C:11]2[C:16]([CH:17]=1)=[C:15]([O:18][CH3:19])[C:14]([O:20][CH3:21])=[C:13]([O:22][CH3:23])[CH:12]=2)(=O)=O.[NH:25]1[CH2:31][CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[CH3:24][N:10]1[C:11]2[C:16](=[C:15]([O:18][CH3:19])[C:14]([O:20][CH3:21])=[C:13]([O:22][CH3:23])[CH:12]=2)[CH:17]=[C:9]1[CH2:8][CH2:7][CH2:6][N:25]1[CH2:31][CH2:30][CH2:29][N:28]([CH2:6][CH2:7][CH2:8][C:9]2[N:10]([CH3:24])[C:11]3[C:16]([CH:17]=2)=[C:15]([O:18][CH3:19])[C:14]([O:20][CH3:21])=[C:13]([O:22][CH3:23])[CH:12]=3)[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 21891574HCID 21891574, compound

Product 1

HCID 21891636HCID 21891636, compound

Procedure

2-(3-Methanesulfonyloxypropyl)-1-methyl-4,5,6-trimethoxyindole (130 mg) and homopiperazine (18 mg) were reacted in the same manner as in Example 1 to obtain the title compound as a free base.

Sources & evidence

ORD record
ord-e0c5bd3bc5304e5086663cd90c813da4
Source dataset
uspto-grants-2006_11
Patent number
US07135473B2

Reaction notes

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