Hexahydro-1,4-diazepine → HCID 178486817, compound

HRID 720348Notes

Reaction equation

HRID 720348 reaction equation
Cl[CH2:2][C:3]1[NH:4][C:5]2[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[C:9]([O:16][CH3:17])=[CH:8][C:6]=2[N:7]=1.[NH:18]1[CH2:24][CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>>[CH3:13][O:12][C:11]1[C:5]2[NH:4][C:3]([CH2:2][N:18]3[CH2:24][CH2:23][CH2:22][N:21]([CH2:2][C:3]4[NH:4][C:5]5[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[C:9]([O:16][CH3:17])=[CH:8][C:6]=5[N:7]=4)[CH2:20][CH2:19]3)=[N:7][C:6]=2[CH:8]=[C:9]([O:16][CH3:17])[C:10]=1[O:14][CH3:15]

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 178486800HCID 178486800, compound

Product 1

HCID 178486817HCID 178486817, compound

Procedure

2-Chloromethyl-4,5,6-trimethoxybenzimidazole (200 mg) and homopiperazine (30 mg) were reacted in the same manner as in Example 1 to obtain the title compound as a free base.

Sources & evidence

ORD record
ord-e989c002a4444752b597acaa6b81a790
Source dataset
uspto-grants-2006_11
Patent number
US07135473B2

Reaction notes

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